Cathelicidin preserves intestinal barrier function in polymicrobial sepsis
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.
Sepsis remains the leading cause of death in critically ill patients, despite modern advances in critical care. Intestinal barrier dysfunction may lead to secondary bacterial translocation and the development of the multiple organ dysfunction syndrome during sepsis. Cyclooxygenase (COX)-2 is highly upregulated in the intestine during sepsis, and we hypothesized that it may be critical in the ma...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2020
ISSN: 1364-8535
DOI: 10.1186/s13054-020-2754-5